Ultrasensitive techniques allow for detection of circulating tumor cells in peripheral blood and disseminated tumor cells in bone marrow. Can CTCs be used as prognostic markers in breast cancer? Breast Cancer Research (Source: Medscape Today Headlines) read more..
Hormone receptor status influences benefit of tamoxifen in DCIS
NEW YORK (Reuters Health) - After lumpectomy and radiation for ductal carcinoma in situ (DCIS), tamoxifen lowers the risk of invasive breast cancer -- but only in women with estrogen receptor (ER)-positive disease, new data show. (Source: Modern Medicine) read more..
Immunohistochemical detection of Polo-like Kinase-1 (PLK1) in primary breast cancer is associated with TP53 mutation and poor clinical outcome
Conclusions:The significant association between elevated PLK1 and TP53 mutation in women with breast cancer is consistent with escape from repression of PLK1 expression by mutant p53. Tumours expressing elevated PLK1, but lacking functional p53, may be potential targets for novel anti-PLK1-targeted drugs. (Source: Breast Cancer Research) read more..