Endogenous estrogens that are synthesized in the body impact gene regulation by activating estrogen receptors in diverse cell types. Exogenous compounds that have estrogenic properties can also be found circulating in the blood in both children and adults. The genome-wide impact of these environmental estrogens on gene regulation is unclear. To obtain an integrated view of gene regulation in response to environmental and endogenous estrogens on a genome-wide scale, we performed ChIP-seq to identify estrogen receptor 1 (ESR1; previously estrogen receptor a) binding sites, and RNA-seq in endometrial cancer cells exposed to bisphenol A (BPA; found in plastics), genistein (GEN; found in soybean), or 17ß-estradiol (E2; an endogenous estrogen). GEN and BPA treatment induces thousands ...MedWorm Sponsor Message: Have a look at The Breast Cancer Daily, the new breast cancer portal with all the latest breast cancer news and research powered by MedWorm, updated daily. read more..
Sunday, 5 January 2014
Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner [RESEARCH]
Saturday, 4 January 2014
New research from the Netherlands shows that the switch from screen film mammography to digital mammography in large, population-based breast cancer screening programs improves the detection of life-threatening cancer without significantly increasing detection of clinically insignificant disease. read more..
Blue dye directed axillary node sampling- revisiting the role
Aim: To evaluate whether combination of Sentinel Lymph Node Biopsy(SLNB) using patent blue dye and four node sampling as a reasonable alternative to SLNB (dual technique), in early breast cancer as guidelines recommend. (Source: International Journal of Surgery) read more..
In a new genetic study, researchers said they may have found a way to cut the cost of genetic screening for breast and ovarian cancers from $3000 to $400. Three teams of infertility scientists in New York and Austria collaborated to study gene mutations that increase a woman's likelihood of breast and ovarian cancers... read more..
This post has nothing to do with cancer… but I think that this site can use an uplifting story… I am so happy to be writing this story. My daughter was adopted at 2 days old. Her Birth Mother selected us from a resume that we compiled. We never met her. She was given two [...] read more..