Cincinnati Children&Amp;#39;S Hospital Medical Center-University Of Notre Dame-Substantial Weight Gain

Examining The Biology Of Tumor-Derived Microvesicles

A new paper by Crislyn D'Souza-Schorey, professor of biological sciences at the University of Notre Dame, discusses the biology of tumor-derived microvesicles and their clinical application as circulating biomarkers. Microvesicles are membrane-bound sacs released by tumor cells and can be detected in the body fluids of cancer patients... read more..

source:http://www.medicalnewstoday.com

Cancer Cells Stopped, Nerve Cells Regenerated By New Candidate Drug

Scientists have developed a small-molecule-inhibiting drug that in early laboratory cell tests stopped breast cancer cells from spreading and also promoted the growth of early nerve cells called neurites. Researchers from Cincinnati Children's Hospital Medical Center report their findings online in Chemistry & Biology... read more..

source:http://www.medicalnewstoday.com

Even mild physical activity may cut breast cancer risk

Physical activity - either mild or intense and before or after menopause - may reduce breast cancer risk, but substantial weight gain may negate these benefits - a new analysis has found. read more..

source:http://www.bignewsnetwork.com

Immunohistochemical Detection-Ductal Carcinoma In Situ-Breast Cancer Research-Invasive Breast Cancer

Clinical Relevance and Biology of CTCsClinical Relevance and Biology of CTCs

Ultrasensitive techniques allow for detection of circulating tumor cells in peripheral blood and disseminated tumor cells in bone marrow. Can CTCs be used as prognostic markers in breast cancer? Breast Cancer Research (Source: Medscape Today Headlines) read more..

source:http://www.medworm.com

Hormone receptor status influences benefit of tamoxifen in DCIS

NEW YORK (Reuters Health) - After lumpectomy and radiation for ductal carcinoma in situ (DCIS), tamoxifen lowers the risk of invasive breast cancer -- but only in women with estrogen receptor (ER)-positive disease, new data show. (Source: Modern Medicine) read more..

source:http://www.medworm.com

Immunohistochemical detection of Polo-like Kinase-1 (PLK1) in primary breast cancer is associated with TP53 mutation and poor clinical outcome

Conclusions:The significant association between elevated PLK1 and TP53 mutation in women with breast cancer is consistent with escape from repression of PLK1 expression by mutant p53. Tumours expressing elevated PLK1, but lacking functional p53, may be potential targets for novel anti-PLK1-targeted drugs. (Source: Breast Cancer Research) read more..

source:http://www.medworm.com