Authors: Porter HA, Carey GB, Keegan AD Abstract The adapters IRS1 and IRS2 link growth factor receptors to downstream signaling pathways that regulate proliferation and survival. Both suppress factor-withdrawal-induced apoptosis and have been implicated in cancer progression. However, recent studies suggest IRS1 and IRS2 mediate differential functions in cancer pathogenesis. IRS1 promoted breast cancer proliferation, while IRS2 promoted metastasis. The role of IRS1 and IRS2 in controlling cell responses to chemotherapy is unknown. To determine the role of IRS1 and IRS2 in the sensitivity of cells to chemotherapy, we treated 32D cells lacking or expressing IRS proteins with various concentrations of chemotherapeutic agents. We found that expression of IRS1, in contrast to IRS2, enh...MedWorm Sponsor Message: Have a look at The Breast Cancer Daily, the new breast cancer portal with all the latest breast cancer news and research powered by MedWorm, updated daily. read more..
Sunday, 5 August 2012
Insulin Receptor Substrate 1 Expression-Growth Factor Receptors-Cancer Pathogenesis
Wednesday, 13 June 2012
Breast Cancer Cells-Breast Cancer Drug-Cancer Treatment-Chest Radiation
A new cancer treatment that links chemotherapy with an agent that homes in on specific breast cancer cells was significantly better than the current drug regimen at keeping patients' advanced tumors from progressing, according to results from a phase III clinical trial. read more..
Chest Radiation for Girls Is Linked to Breast Cancer Later
Women who were exposed to chest radiation to treat cancer during childhood have a risk of developing breast cancer as adults that is comparable to that of women with a high genetic risk of the disease, according to a study being presented Monday. (Source: WSJ.com: Health) read more..
Genentech's Trastuzumab Emtansine (T-DM1) Reduces The Risk Of Cancer Worsening
Roche announced today that it's division, known as Genentech, has produced positive results in a phase three EMILIA study of a drug called trastuzumab emtansine (T-DM1). Genentech says that the drug met the endpoint target for the trial, showing marked improvement for women with HER2-positive metastatic breast cancer... read more..
Inflammation Of The Liver-Viruses And Bacteria-Therapy Options-Gene Expression-Breast Cancer
A study led by Vanderbilt-Ingram Cancer Center (VICC) investigators has identified a gene expression pattern that may explain why chemotherapy prior to surgery isn't effective against some tumors and suggests new therapy options for patients with specific subtypes of breast cancer. The study by lead author Justin Balko, Pharm.D., Ph.D... read more..
Scientists Offer New Clues
Chronic inflammation of the liver, stomach or colon, often as a result of infection by viruses and bacteria, is one of the biggest risk factors for cancer of these organs. Scientists at the ... read more..
Thursday, 7 June 2012
American Society Of Clinical Oncology-Cancer-Related Fatigue-Non-Hodgkin Lymphoma
A new cancer treatment that links chemotherapy with an agent that homes in on specific breast cancer cells was significantly better than the current drug regimen at keeping patients' advanced tumors from progressing, according to results from a Phase III clinical trial led by Kimberly Blackwell, M.D., of the Duke Cancer Institute... read more..
Cancer Patients Fight Fatigue With Ginseng
High doses of the herb American ginseng (Panax quinquefolius) over two months reduced cancer-related fatigue in patients more effectively than a placebo, a Mayo Clinic-led study found. Sixty percent of patients studied had breast cancer. The findings were presented at the American Society of Clinical Oncology's annual meeting... read more..
Type 2 diabetes ups risk of developing blood cancer by 20pc
Patients with type 2 diabetes have a 20 percent increased risk of developing blood cancers, such as non-Hodgkin lymphoma, leukemia and myeloma, according to a new meta-analysis. read more..
Sunday, 20 May 2012
Do We Really Need a Bald Barbie Doll?
A bald Barbie is a wonderful idea as long as you provide wigs. Bald may be beautiful, but many of us like the option of hair. read more..
Saturday, 12 May 2012
Breast Cancer Patient-Breast Cancer Tumors-Patient Response-Gene Expression-Chemotherapy
Two new gene expression signatures can predict how breast cancer tumors will respond to two of the common kinds of chemotherapy, highlighting the potential of target-based gene expression indices to predict patient response to drug therapy. (Source: BioMed Central) read more..
Friday, 4 May 2012
Breast Cancer
Recently I saw an exciting ABC News report concerning a woman who was pregnant with twins when she received a diagnosis of breast cancer. Because it was stage 3 cancer, the doctor advised her to being chemotherapy immediately. read more..
Monday, 2 April 2012
Inflammatory Breast Cancer-Chemotherapy-Trastuzumab-Bevacizumab
Neoadjuvant treatment with bevacizumab, trastuzumab, and chemotherapy was efficacious and well tolerated in patients with previously untreated primary inflammatory breast cancer. Further confirmation of use of bevacizumab in inflammatory breast cancer is needed. (Source: The Lancet Oncology) read more..
Sunday, 25 March 2012
Photoacoustic Tomography-New Imaging Technology-Photoacoustic Imaging-Chemotherapy Drugs
Scientists have uncovered a marker of DNA damage that could predict who will respond to platinum-based chemotherapy drugs like cisplatin or carboplatin. These drugs are widely used for ovarian cancer, but as with most cancer drugs, it can be difficult to predict who will respond to therapy... read more..
Photoacoustic Imaging Moves From Lab To Clinic
Every new imaging technology has an aura of magic about it because it suddenly reveals what had been concealed, and makes visible what had been invisible. So, too, with photoacoustic tomography, which is allowing scientists to virtually peel away the top several inches of flesh to see what lies beneath... read more..
Saturday, 24 March 2012
Cognitive Behavioral Therapy-Urinary Incontinence-Distressing Symptoms-Menopausal Symptoms
(ECCO-the European CanCer Organisation) Researchers from the Netherlands have found that the menopausal symptoms caused by giving chemotherapy or hormonal therapy to younger women with breast cancer can be ameliorated considerably through the use of cognitive behavioral therapy and physical exercise. These interventions can be effective in dealing with such distressing symptoms as hot flushes, night sweats, vaginal dryness, weight gain, urinary incontinence and sexual problems, the researchers say. (Source: EurekAlert! - Medicine and Health) read more..
Bartow Teen Fought Cancer and Is Back in Class
A 14-year-old Bartow teenager, Bustos-Fernandez thought she'd be running up and down a soccer field or sitting in a classroom tackling middle school math.But that didn't happen.Cancer ... read more..
Cognitive Behavioral Therapy-Urinary Incontinence-Distressing Symptoms-Menopausal Symptoms
Researchers from The Netherlands have found that the menopausal symptoms caused by giving chemotherapy or hormonal therapy to younger women with breast cancer can be ameliorated considerably through the use of cognitive behavioral therapy (CBT)[1] and physical exercise (PE). These interventions can be effective in dealing with such distressing symptoms as hot flashes, night sweats, vaginal dryness, weight gain, urinary incontinence and sexual problems, a researcher told the 8th European Breast Cancer Conference (EBCC-8)... (Source: Health News from Medical News Today) read more..
Symptoms Of Treatment-Induced Menopause In Breast Cancer Patients Eased By Non-Drug Treatments
Researchers from The Netherlands have found that the menopausal symptoms caused by giving chemotherapy or hormonal therapy to younger women with breast cancer can be ameliorated considerably through the use of cognitive behavioral therapy (CBT)[1] and physical exercise (PE)... read more..
Tuesday, 20 March 2012
Journal Of The American Association For Cancer Research-National Cancer Centre Singapore
(National University of Singapore) Researchers from the National University of Singapore and National Cancer Centre Singapore found that Asians breast cancer sufferers undergoing chemo develop memory loss and decision-making and speech problems. (Source: EurekAlert! - Cancer) read more..
Dietary cadmium may be linked with breast cancer risk
(American Association for Cancer Research) Dietary cadmium, a toxic metal widely dispersed in the environment and found in many farm fertilizers, may lead to an increased risk of breast cancer, according to a study published in Cancer Research, a journal of the American Association for Cancer Research. (Source: EurekAlert! - Biology) read more..
CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer
Conclusions:CD8+ tumor infiltrating lymphocytes are an independent prognostic factor associated with better patient survival in basal-like breast cancer, but not in non-basal triple negative breast cancers nor in other intrinsic molecular subtypes. (Source: Breast Cancer Research) read more..
Monday, 19 March 2012
Chemotherapy Treatment-White Blood Cells-Breast Cancer-Chemo Drugs
I was talking to someone recently who is undergoing chemotherapy for breast cancer. She was alarmed at her increased risk for infection and illness because of the effect of the chemo drugs on her blood cells. One of the more serious complications of chemotherapy treatment is a reduction in the number of white blood cells, [...] read more..