Endogenous estrogens that are synthesized in the body impact gene regulation by activating estrogen receptors in diverse cell types. Exogenous compounds that have estrogenic properties can also be found circulating in the blood in both children and adults. The genome-wide impact of these environmental estrogens on gene regulation is unclear. To obtain an integrated view of gene regulation in response to environmental and endogenous estrogens on a genome-wide scale, we performed ChIP-seq to identify estrogen receptor 1 (ESR1; previously estrogen receptor a) binding sites, and RNA-seq in endometrial cancer cells exposed to bisphenol A (BPA; found in plastics), genistein (GEN; found in soybean), or 17ß-estradiol (E2; an endogenous estrogen). GEN and BPA treatment induces thousands ...MedWorm Sponsor Message: Have a look at The Breast Cancer Daily, the new breast cancer portal with all the latest breast cancer news and research powered by MedWorm, updated daily. read more..
Sunday 5 January 2014
Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner [RESEARCH]
Saturday 4 January 2014
Digital mammography improves population-based breast cancer screening
New research from the Netherlands shows that the switch from screen film mammography to digital mammography in large, population-based breast cancer screening programs improves the detection of life-threatening cancer without significantly increasing detection of clinically insignificant disease. read more..
Blue dye directed axillary node sampling- revisiting the role
Aim: To evaluate whether combination of Sentinel Lymph Node Biopsy(SLNB) using patent blue dye and four node sampling as a reasonable alternative to SLNB (dual technique), in early breast cancer as guidelines recommend. (Source: International Journal of Surgery) read more..
Genetic Researchers Find New, Low-Cost Approach For Ovarian And Breast Cancer Testing
In a new genetic study, researchers said they may have found a way to cut the cost of genetic screening for breast and ovarian cancers from $3000 to $400. Three teams of infertility scientists in New York and Austria collaborated to study gene mutations that increase a woman's likelihood of breast and ovarian cancers... read more..
Uplifting Story-Mary
This post has nothing to do with cancer… but I think that this site can use an uplifting story… I am so happy to be writing this story. My daughter was adopted at 2 days old. Her Birth Mother selected us from a resume that we compiled. We never met her. She was given two [...] read more..
Wednesday 3 October 2012
Running notebook New cancer research benefit coming Oct. 6
For the past 22 years, the first Saturday in October has been reserved for the Houston Komen Race for the Cure. The city's largest walking and running event, it now draws more than 35,000 people ... read more..
New Drug Shows Promise in Breast Cancer Clinical Trials
A recent press release reports that the antibody-drug conjugate Trastuzumab Emtansine or T-DM1 has "significantly improved survival in the EMILIA Phase III Trial." This run of clinical trials was to establish the efficacy of T-DM1 in treating cases of metastatic HER-2 positive breast cancer. Patients enrolled on the trial had already been treated with taxane chemotherapy and Herceptin. read more..
Friday 28 September 2012
Republican Presidential Nominee Mitt Romney-Older Americans
WASHINGTON (Reuters) - Even before his running mate was booed by a lobbying group for older Americans on Friday, Republican presidential nominee Mitt Romney was losing support among such voters, whose backing is crucial to his hopes of winning the... read more..
Monday 24 September 2012
Breast Conserving Surgery-Treatment Decisions-Breast Cancer Care-Treatment Choice
AbstractThe practice of offering choice to those women with breast cancer for whom either breast conserving surgery or mastectomy would be equally beneficial has come to be seen as an important aspect of medical care. As well as improving satisfaction with treatment, this is seen as satisfying the ethical principle of respect for autonomy. A number of studies, however, show that women are not always comfortable with such choice, preferring to leave treatment decisions to their surgeons. A question then arises as to the extent that these women can be seen as autonomous or as exercising autonomy. This paper argues, however, that the understanding of autonomy which is applied in current approaches to breast cancer care does not adequately support the exercise of autonomy, and that the clinic...MedWorm Sponsor Message: Have a look at The Breast Cancer Daily, the new breast cancer portal with all the latest breast cancer news and research powered by MedWorm, updated daily. read more..